Endocrine Abstracts

Background: Metabolic complications with obesity are frequent in childhood acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). Childhood onset Craniopharyngioma (CP) survivors without hypothalamic (HT) involvement are spared gross obesity. Magnetic resonance diffusion tensor imaging (DTI) provides information of microstructure function of the brain and quantified as fractional anisotrophy (FA), mean diffusivity (MD), axial and radial diffusivi...

Background: Metabolic complications (obesity, lipid abnormalities, and insulin resistance) are prevalent in acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). The hypothalamus (HT) is a complex area involved in endocrine function and metabolic control. In ALL survivors, assessment of the volume of the HT in relation to metabolic parameters including ghrelin, a peptide stimulating food intake, has not been performed previously.<p class="ab...

Background: Hypothalamic damage caused by craniopharyngioma (CP) is related to memory deficits, disturbed attention, and impaired processing speed. This is the first study that aims to establish a structure to function relationship by assessing cognitive function in adult patients with childhood-onset (CO) CP along with volumetric analysis of the hypothalamus.Method: Forty-one (24 women) surgically treated CO-CP patients (median age at diagnosis; 11 year...

Introduction: Adult patients with craniopharyngioma (CP) and hypothalamic (HT) damage have impaired cognitive function. The white matter (WM) changes behind these findings remain to be elucidated. Diffusion tensor imaging (DTI) is a MRI technique that quantifies microstructural damage in the WM. This is the first study of DTI, hippocampal (HC) and HT volume in relation to cognition in CP patients.Methods: A cross-sectional study of childhood onset CP was...

Background/objectives: Hypothalamic obesity (HO) occurs in 50% of patients with the pituitary tumor Craniopharyngioma (CP). Attempts have been made to predict the risk of HO based on hypothalamic (HT) damage on magnetic resonance imaging (MRI), but none have included volumetry. Qualitative and quantitative (volumetric) analyses of HT damage was performed. The results were explored in relation to feeding related peptides and body fat.Subjects/methods: A c...